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    Schematic of micromotor toxoids for oral vaccination [Image 1 of 3]

    Schematic of micromotor toxoids for oral vaccination

    FORT BELVOIR, VA, UNITED STATES

    12.13.2019

    Courtesy Photo

    Defense Threat Reduction Agency's Chemical and Biological Technologies Department

    Micromotor nanotoxoids are fabricated in a sequential process (a). When micromotor toxoids are administered orally to mice (b), the enteric coating protects the formulation from degradation in the low gastric pH. Then, the enteric coating dissolves in the neutral pH of the intestine, and the intestinal fluid activates the micromotors. The autonomous propulsion facilitates enhanced retention, promoting immunity.

    Source: Wei X, Beltrán-Gastélum M, Karshalev E, et al. 2019. Biomimetic micromotor enables active delivery of antigens for oral vaccination. Nano Lett. 19(3):1914–1921. doi: 10.1021/acs.nanolett.8b05051.

    Image courtesy of Dr. Liangfang Zhang.

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    IMAGE INFO

    Date Taken: 12.13.2019
    Date Posted: 12.13.2019 11:29
    Photo ID: 5978245
    VIRIN: 191213-A-AB123-001
    Resolution: 1221x960
    Size: 192.92 KB
    Location: FORT BELVOIR, VA, US 

    Web Views: 35
    Downloads: 4

    PUBLIC DOMAIN