WEBVTT

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The tissue foundry is a platform . It

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demonstrates the best of today's

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technologies for scalable , modular ,

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automated and closed manufacturing and

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serves as a test bed for technologies

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that are in development in our

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ecosystem . The reason that we decided

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to actually build a tissue foundry here

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is the more we looked at all the needs

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of our nearly 200 members of army is

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almost all of them have a very

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different goal , a kidney , a liver ,

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but they all have the same problems .

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And since they all need to share some

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pre competitive baseline engineering

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capabilities , why should they all

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spend their time and money developing

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them separately ? Let's develop them

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once let's develop them , right . Let's

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make it world class and let's share it .

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And as this foundry starts producing

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one and then another and then another

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organ , all of our members will get to

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share the baseline capabilities they're

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developing and bring to it . The

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special expertise they have . All of

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these companies will benefit from the

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collective capability of the

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engineering community and then the

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public will benefit because we will

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scale up as quickly as we possibly can .

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The ability to make the cells tissues

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and organs that people need . The

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vision behind the tissue foundry is to

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enable bio fab usa members , the

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ability to take their production of

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cells , tissues and organs from a scale

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that's at the bench top to a more

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scalable cost effective and consistent

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method through an integrated system of

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automation equipment and sensors .

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That's scalable , modular , automated

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and closed . For designing the line we

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really try to take to heart . Uh the

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the key concepts that bio fab espoused .

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So really try to look at the key

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modules that we wanted to be part of

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this uh expansion culture , starting to

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take the cells and grow them up ,

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harvest and wash , concentrate them

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down , so we can move them on to the

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the tissue bi reactor . And lastly ,

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the tissue assembly and maturation

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module where we could form the tissue

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and grow it out . When we started the

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design for the tissue foundry , it was

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mostly a proof of concept project .

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Could we actually fully automate tissue

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fabrication from cells all the to an

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end product ? But along the way , it's

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actually served several other really

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useful purposes . It helped us identify

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several challenges and gaps in the

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technology that we believe will be

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really necessary to make this and get

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it over the line to something that's

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commercialized manufactur . So it

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should be kept in mind that the tissue

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foundry line is really a collaborative

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process . We work very closely with the

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bio fab team in terms of doing

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automation gap assessments for all new

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processes that we're going to

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implementing in the line , trying to

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understand where there are potential

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gaps and then doing a lot of research

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and development , trying to identify

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new pieces of equipment , new ways of

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doing processes , ways that we

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currently do things for other projects

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that may be applicable to the new

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process that we're trying to evaluate .

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We are working with bio fab USA to

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convert our manual class process for

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generating sim cell drive islet cells

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into an automated manufacturing process .

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We hope that by automating and closing

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this manufacturing process that we can

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reduce these pilot cells with greater

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quality reliability and rep stability

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than is possible with the manual

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process that we have currently . In

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addition , we are developing approaches

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for storing these cells and shipping

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them worldwide . A major challenge in

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the field of type one diabetes research

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which JDRF supports is a lack of access

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to these very important cells for their

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research . Here , we hope that by

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automating and closing the

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manufacturing process that we can

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generate stem cells with greater

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reproducibility , reliability and

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quality than is possible with the

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manual process when successful the

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tissue foundry and its ability to

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produce cells , tissues and organs in a

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scalable modular automated and closed

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fashion will become the industry

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standard of tissue manufacturing and

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enable bio fab usa members to take

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their process from the clutches of the

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valley of death into a more consistent

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cost effective and commercially viable

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production . What makes bio fab usa

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unique is that here , we're actually

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building the manufacturing line of the

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future . We are developing new

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technologies that can be implemented on

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that line through our technology

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development projects . We also have a

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process development team to analyze

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your process and see how we can then

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implemented onto that manufacturing

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line . And we're conducting a deep

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tissue characterization necessary to

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really understand your process as well

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as complementing that with a regulatory

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and education workforce development

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program so that you can actually

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adequately staff that line when it's in

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production .