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    A Breath of Fresh Air: Botulism Antidote in Development [Image 1 of 3]

    A Breath of Fresh Air: Botulism Antidote in Development

    FORT BELVOIR, VA, UNITED STATES

    05.23.2018

    Courtesy Photo

    Defense Threat Reduction Agency's Chemical and Biological Technologies Department

    A single dose of Cyto-111 provides protection in mice at times refractory to
    antitoxin treatment. Mice lethally intoxicated with 2x LD50 BoNT/A become
    symptomatic between 6-8 hours after intoxication. Treatment was initiated
    with a single dose of Cyto-111 or antitoxin (sufficient to neutralize 10,000x
    LD50) administered at different times post-intoxication. Whereas a single
    treatment of Cyto-111 significantly protected mice from death at all time
    points, antitoxin was only partially effective at 6 hours after intoxication,
    and became less effective at longer treatment latencies. This data indicates
    that intraneuronal activity of Cyto-111 reverses symptoms of botulism at time
    when current standard-of-care fails. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.
    (Image courtesy of Konstantin Ichtchenko, Ph.D.)

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    IMAGE INFO

    Date Taken: 05.23.2018
    Date Posted: 05.23.2018 09:11
    Photo ID: 4413862
    VIRIN: 180523-A-AB123-001
    Resolution: 2907x2378
    Size: 455.73 KB
    Location: FORT BELVOIR, VA, US 

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