A Breath of Fresh Air: Botulism Antidote in Development [Image 1 of 3]

FORT BELVOIR, VA, UNITED STATES

05.23.2018

Courtesy Photo

Defense Threat Reduction Agency's Chemical and Biological Technologies Department

A single dose of Cyto-111 provides protection in mice at times refractory to
antitoxin treatment. Mice lethally intoxicated with 2x LD50 BoNT/A become
symptomatic between 6-8 hours after intoxication. Treatment was initiated
with a single dose of Cyto-111 or antitoxin (sufficient to neutralize 10,000x
LD50) administered at different times post-intoxication. Whereas a single
treatment of Cyto-111 significantly protected mice from death at all time
points, antitoxin was only partially effective at 6 hours after intoxication,
and became less effective at longer treatment latencies. This data indicates
that intraneuronal activity of Cyto-111 reverses symptoms of botulism at time
when current standard-of-care fails. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.
(Image courtesy of Konstantin Ichtchenko, Ph.D.)

• Date Taken: 05.23.2018
• Date Posted: 05.23.2018 09:11
• Photo ID: 4413862
• VIRIN: 180523-A-AB123-001
• Resolution: 2907x2378
• Size: 455.73 KB
• Location: FORT BELVOIR, VA, US